Learning Objectives:

1. Utilize a rational approach to polytherapy with antiepileptic drugs.
2. Describe fundamentals of patch clamp electrophysiology, and how it is used to study mechanisms of antiepileptic drugs
3. Specify ion channels affected by different antiepileptic drugs, as well as examples of models in which they are studied
4. Explain Hodgkin and Huxley’s contribution to the fields of electrophysiology and computational neuroscience
5. Discuss how computer models could be used to predict effective antiepileptic drug polytherapy