WMJ Vol 122 Issue 5: Uptake Rates of Three COVID-19 Vaccine Doses and Risk Factors for Incomplete Vaccination Among Patients With Inflammatory Bowel Disease Residing in Wisconsin: A Single-Center Cohort

ABSTRACT

Introduction: Patients with inflammatory bowel disease on systemic corticosteroids may be at higher risk of adverse outcomes of COVID-19 infection, and vaccination is an essential preventive measure. Uptake of the original 2-dose COVID-19 messenger RNA (mRNA) primary vaccine series was previously high among patients with inflammatory bowel disease, while uptake of subsequent doses based on interval recommendations made by the Advisory Committee on Immunization Practice remains unknown. Herein, we evaluated uptake of 3 COVID-19 mRNA vaccine doses among patients with inflammatory bowel disease.

Methods: We performed a single-center, retrospective study evaluating COVID-19 vaccine uptake among adult patients with inflammatory bowel disease residing in Wisconsin who were seen at the University of Wisconsin Digestive Health Center. Vaccination status as of April 30, 2022, was verified in the Wisconsin Immunization Registry. A multivariable logistic regression was performed with the primary endpoint of receipt of 3 COVID-19 vaccine doses. Secondary outcomes included identification of demographic and clinical variables associated with incomplete vaccination.

Results: A total of 1012 patients were identified; 728 (71.9%) patients received 3 COVID-19 vaccine doses. Multivariable logistic regression revealed that younger age (odds ratio [OR] 1.02; 95% CI, 1.01 – 1.03; P = 0.001), rural status (OR 3.44; 95% CI, 2.17 – 5.56; P < 0.001), underrepresented minority status (OR 3.85; 95% CI, 1.89 – 7.69; P < 0.001), and absence of influenza vaccination (OR 8.17; 95% CI, 5.41 – 12.33; P < 0.001) were significantly associated with incomplete COVID-19 vaccination.

Conclusions: Receipt of 3 COVID-19 mRNA vaccine doses is high overall among patients with inflammatory bowel disease. Younger age, underrepresented race/ethnicity, rural status, and lack of influenza vaccination are associated with incomplete COVID-19 vaccination.

 

Intended Audience

The target audience for this journal-based activity is healthcare providers caring for the people and communities of Wisconsin and beyond.

Learning Objectives

As a result of this journal-based activity, learners, as members of the healthcare team, will be able to:

  1. Summarize the primary outcome of a single-center, retrospective study—rates of three COVID-19 vaccine doses among adult patients with inflammatory bowel disease.
  2. Evaluate the secondary outcomes of this study, including demographic and clinical variables associated with incomplete COVID-19 vaccination.
  3. Discuss how clinical teams, including those caring for immuno­suppressed patient populations, could improve COVID-19 vaccina­tion.
Course summary
Available credit: 
  • 1.00 AAPA Category 1 CME
  • 1.00 ACPE Contact Hours - Pharmacist
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC Contact Hours
  • 1.00 University of Wisconsin–Madison Continuing Education Hours
    • 1.00 Approved for AMA PRA Category 1 Credit™
Registration opens: 
08/22/2024
Course expires: 
08/21/2025
Cost:
$0.00
Part of: 
Wisconsin Medical Journal Volume 122
Rating: 
0

FACULTY DISCLOSURE

It is the policy of the University of Wisconsin–Madison Interprofessional Continuing Education Partnership (ICEP) to identify, mitigate and disclose all relevant financial relationships with ineligible companies* held by the speakers/presenters, authors, planners, and other persons who may influence content of this accredited continuing education (CE). In addition, speakers, presenters and authors must disclose any planned discussion of unlabeled/unapproved uses of drugs or devices during their presentation.

For this accredited continuing education activity all relevant financial relationships have been mitigated and detailed disclosures are listed below.

Name of IndividualIndividual's Role in Activity

Financial Relationship Disclosure

Discussion of
Unlabeled/Unapproved
Uses of Drugs/Devices
in Presentation?

Trevor L. Schell, MDAuthorNo relevant relationships with ineligible companies to discloseNo
Miguel A. Mailig, BSAuthorNo relevant relationships with ineligible companies to discloseNo
Mazen Almasry, MBBSAuthorNo relevant relationships with ineligible companies to discloseNo
Sarah Lazarus, BSAuthor  
Luke J. Richard, MDAuthor  
Katharine Tippins, BSAuthorNo relevant relationships with ineligible companies to discloseNo
Jennifer Weiss, MD, MSAuthor  
Mary S. Hayney, PharmD, MPHAuthor  
Freddy Caldera, DO, MSAuthor  
Cezarina Mindru, MDReviewerNo relevant relationships with ineligible companies to discloseNo
Christopher J. Crnich, MDReviewer No relevant relationships with ineligible companies to discloseNo
Fahad Aziz, MDEditor No relevant relationships with ineligible companies to discloseNo
Roberta Pawlak, PhD, RN, NEA-BC Reviewer No relevant relationships with ineligible companies to discloseNo
Cassie Meffert, PAReviewer No relevant relationships with ineligible companies to discloseNo
Shezad BalochAccreditation SpecialistNo relevant relationships with ineligible companies to disclose 

*Ineligible companies are those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on, patients.

The ACCME does not consider providers of clinical services directly to patients to be ineligible companies.

Discloser List CME Internal Report

Accreditation

Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the University of Wisconsin–Madison ICEP and the Wisconsin Medical Journal.  The University of Wisconsin–Madison ICEP is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Credit Designation Statements

American Medical Association (AMA)

The University of Wisconsin–Madison ICEP designates this journal-based CE activity for a maximum of 1.0 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Nurses Credentialing Center (ANCC)   

The University of Wisconsin–Madison ICEP designates this journal-based CE activity for a maximum of 1.0 ANCC contact hours .  

The University of Wisconsin–Madison ICEP has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1 AAPA Category 1 CME credits. Approval is valid until 08/21/2025. PAs should only claim credit commensurate with the extent of their participation.    

Continuing Education Units

The University of Wisconsin–Madison ICEP, as a member of the University Professional & Continuing Education Association (UPCEA), authorizes this program for 0.1 continuing education units (CEUs) or 1 hour.

Available Credit

  • 1.00 AAPA Category 1 CME
  • 1.00 ACPE Contact Hours - Pharmacist
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC Contact Hours
  • 1.00 University of Wisconsin–Madison Continuing Education Hours
    • 1.00 Approved for AMA PRA Category 1 Credit™

Cost:
$0.00
Please login or register to take this course.

Registration for this activity can only be completed through the ICEP Learning Portal. Attendee registrations made through any other sites cannot be honored. UW-Madison ICEP is not able to refund fees paid through unaffiliated registration sites, such as eMedEvents.com, MedConfWorld.com, EventEgg.com, and 10times.com. Please report any unauthorized websites or solicitations for registrations to help@icep.wisc.edu.

Accessibility

The University of Wisconsin provides equal opportunities in employment and programming, including Title IX requirements. The University of Wisconsin fully complies with the legal requirements of the ADA and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please notify us at help@icep.wisc.edu

Required Hardware/software

Free, current version of Chrome, Firefox, Safari, or Edge. Some older browsers and Microsoft Internet Explorer could produce error messages or not display the content correctly. 

Free, current version of Adobe Acrobat Reader or other .pdf reader.